Still untarnished by the false promises of the rapacious film industry, the wide-eyed actress, Betty, sets foot on bustling, sun-kissed Hollywood. Brimming with hope, and eager to spread her wings and prove her worth, Betty moves in Aunt Ruth's expensive apartment, unbeknownst to her, however, that fate has other plans in store for her, setting the stage for life-altering experiences with the unexpected, the indecipherable, and the unknown. Now, in the centre of an elaborate labyrinth of half-truths, faded memories, unrequited loves, and dangerous encounters with the city's ugly face lies a strange key to a mysterious keyhole, an even stranger indigo-blue cube, the young director, Adam, and one cryptic woman: the amnesiac brunette and devilishly seductive car-crash survivor, Rita. But, time flies and Rita's opaque past demands answers. After all, both women deserve the truth. What is the secret of the serpentine, dream-crushing Mulholland Drive?

This film views the mob lives of three pivotal figures in the 1960's and 70's New York. Henry Hill is a local boy turned gangster in a neighborhood full of the roughest and toughest. Tommy DeVito is a purebred gangster, who turns out to be Henry's best friend. Jimmy Conway puts the two of them together, and runs some of the biggest hijacks and burglaries the town has ever seen. After an extended jail sentence, Henry must sneak around the back of the local mob boss, Paulie Cicero, to live the life of luxury he has always dreamed of. In the end, the friends end up in a hell of a jam, and must do anything they can to save each other, and stay alive.